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src="https://omo-oss-image.thefastimg.com/portal-saas/new2023042821215034000/cms/image/92c68472-952e-469f-b685-5a82174f7878.png" style="max-width: 100%; width: auto; height: auto;" /></p> <p style="text-align: center;"> </p> <p style="text-align: center;"><span style="color:#3498db;"><strong><span style="font-size:18px;">妗堜緥涓€ mRNA鍔犲附鍒嗘瀽</span></strong></span></p> <p>鐪熸牳鐢熺墿涓殑甯藉瓙缁撴瀯鍦ㄧ炕璇戣捣濮嬪洜瀛愮殑鎷涘嫙杩囩▼涓捣鐫€闈炲父閲嶈鐨勪綔鐢紝鍚屾椂鍦ㄨ優璐ㄤ腑杩樺彲浠ラ槻姝RNA琚檷瑙ｏ紝鍥犳鍔犲附鏁堢巼鏄痬RNA鐢熶骇杩囩▼涓殑閲嶈鍙傛暟涔嬩竴銆傞敭鍑鎶€鍒嗘瀽鏂规硶寮€鍙戦儴鍥㈤槦寮€鍙戜簡鍩轰簬HRMS琛ㄥ緛mRNA鍔犲附鐜囩殑鏂规硶锛岃鏂规硶浣跨敤楂樺垎杈ㄨ川璋变华缁撳悎鏍歌嫹閰镐笓鐢ㄨ壊璋辨煴锛屽湪杈冪煭鏃堕棿鍐呭畬鎴愬揩閫熷垎鏋愩€侟/p> <p style="text-align: center;"><img id="1719621789577469952" src="https://omo-oss-image.thefastimg.com/portal-saas/new2023042821215034000/cms/image/dcf78878-102d-4754-8dba-a885b36b6c0c.png" style="max-width: 100%; width: auto; height: auto;" /></p> <p> </p> <p style="text-align: center;"><span style="color:#3498db;"><strong><span style="font-size:18px;">妗堜緥浜 mRNA鍔犲熬鍒嗘瀽</span></strong></span></p> <p>mRNA 鐨凱olyA灏惧反鏈夊姪浜庣淮鎸乵RNA鐨勭ǔ瀹氭€с€佽繍杈撳拰杞瘧鏁堢巼锛屽奖鍝嶇潃mRNA鐨勫崐琛版湡銆傞敭鍑鎶€鍒嗘瀽鏂规硶寮€鍙戦儴鍥㈤槦鍒╃敤鐗瑰畾鐨勬牳绯栨牳閰搁叾锛圧Nase T1锛夊mRNA灏惧反杩涜鍒囧壊锛岀粨鍚圤ligo dT mRNA绾寲璇曞墏鐩掞紝浣跨敤楂樺垎杈ㄨ川璋变华鍙〃寰乸olyA灏剧殑鍒嗗瓙閲忥紝纭畾闀垮害鍙婂垎甯冦€侟/p> <p style="text-align: center;"><img id="1719621846867468288" src="https://omo-oss-image.thefastimg.com/portal-saas/new2023042821215034000/cms/image/ac7ce1bb-78fb-4cdb-97b3-00991204e0dd.png" style="width: 1017px; height: 472px; max-width: none;" /></p> <p style="text-align: center;"> </p> <p style="text-align: center;"> </p> <p style="text-align: center;"><span style="color:#3498db;"><strong><span style="font-size:18px;">妗堜緥涓 CGE-LIF鍒嗘瀽mRNA绾害</span></strong></span></p> <p>鍦ㄧ敓浜с€佸姞宸ャ€侀暱鏈熷偍瀛樿繃绋嬩腑锛宮RNA閮藉彲鑳藉彂鐢熼檷瑙ｅ奖鍝嶅叾绾害鍙婂畬鏁存€э紝mRNA绾害鍙婂畬鏁存€у浜巑RNA浜у搧鐨勮川閲忎繚璇佽嚦鍏抽噸瑕併€傚垎鏋愰敭鍑鎶€鍒嗘瀽鏂规硶寮€鍙戝洟闃熷紑鍙戝熀浜庢瘺缁嗙鐢垫吵浠紝閲囩敤CGE-LIF鏂规硶琛ㄥ緛mRNA绾害鍙婂畬鏁存€э紝璇ユ柟娉曡嚜鍔ㄥ寲绋嬪害楂橈紝鍒嗙閫熷害蹇紝鍒嗚鲸鐜囬珮涓斿畾閲忓噯纭€侟/p> <p style="text-align: center;"><img id="1719622331093897216" 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style="text-align: center;"> </p> <p style="text-align: center;"><span style="text-align:center;"><span style="color:#3498db;"><strong><span style="font-size:18px;">閿嚡绉戞妧搴旂敤鍒涙柊骞冲彴鍦ㄦ牳鑻烽吀鑽墿棰嗗煙鐨勬湇鍔′紭鍔军/span></strong></span></span></p> <p> </p> <p><span style="text-align:center;"><span style="color:#2980b9;">鈻 </span>鑷富鐭ヨ瘑浜ф潈鐨勮仛涔欎簩閱囧寲鎶€鏈細瀵硅泲鐧借川銆佽偨銆佸鏍歌嫹閰稿拰灏忓垎瀛愮瓑瀹炵幇鐙壒鐨凱EG鍖栦慨楗帮紝涔熸秹鍙婇€掗€佽浇浣撱€佽剛璐ㄤ綋銆佹按鍑濊兌銆丩inker绛夌粨鏋勭殑瀹氬埗鍖栨湇鍔狘/span></p> <p><span style="text-align:center;"><span style="color:#2980b9;">鈻 </span>PEG棰嗗煙绮捐€曠粏浣滐紝涓撲笟鐨勭悊瑙ｏ細绉疮浜?000浣欑浜у搧锛岀洰褰曚骇鍝佽秴杩?00绉嶏紝鏄浗鍐呭灏戞暟鑳藉鑷富瑙勬ā鍖栫敓浜ч珮绾害銆佷綆鍒嗘暎鎬ц仛涔欎簩閱囩殑浼佷笟</span></p> <p><span style="text-align:center;"><span style="color:#2980b9;">鈻 </span>鑷湁楂樼鐮斿彂璁惧锛屾敮鎸佸鏉傛潗鏂欑殑鍒涙柊鐮斿彂宸ヤ綔</span></p> <p><span style="text-align:center;"><span style="color:#2980b9;">鈻 </span>PEG鍏ㄧ幆鑺傚畾鍒舵湇鍔★細浠庡師鏂橮EG鍖栧悎鐗╃瓫閫夛紝宸ヨ壓浼樺寲锛屼慨楗拌〃寰侊紝璐ㄩ噺鍒嗘瀽锛屽埌娉ㄥ唽涓庣敵鎶ワ紝鍚勬ā鍧椾笓涓氬寲鍥㈤槦銆侟/span></p> <p style="text-align: center;"><img id="1719623687879938048" 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